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      Autoimmunity and Hypothyroidism

      a , b

      Hormone Research in Paediatrics

      S. Karger AG

      Thyroiditis, Hypothyroidism, Autoimmunity, Thyroid antibodies

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          Primary myxedema and hypothyroid Hashimoto’s disease provide a well-documented example of organ-specific autoimmunity in man. Very slight modifications or increased release of thyroglobulin or thyroid antigens in the circulation may cause the rupture of autotolerance for the normal thyroid components, at least when individuals have a genetic predisposition to autoimmune thyroiditis (possibly associated with a predisposition to other autoimmune diseases). The demonstration of an association between HLA and thyroiditis, however, requires additional studies. The basic immunological abnormality responsible for autoimmunization against thyroid components is a defect in suppressor T cells, shown in experimental animals but not firmly established in man. The result of autoimmunization will be the appearance of cytotoxic mechanisms that lead to destruction of the thyroid follicle with progressive fibrosis, antibody-dependent cell-mediated cytotoxicity apparently being of major importance. A recent report shows, in addition, that thyroid atrophy in primary hypothyroidism is associated with the production of antibodies that block the thyroid-growth-promoting activity of TSH. The recent progress made in our understanding of autoimmune thyroiditis will certainly contribute to improving our knowledge of how and when autoimmunization might develop in man.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 16
          : 5
          : 329-337
          aService d’lmmunologie (Prof. A. Capron), UER de Médecine, Université de Lille, et bServices de Médecine Générale et Endocrinologie (Prof. M. Linquette) et d’Endocrinologie et Diabétologie (Prof. P. Fossati), CHR de Lille, France
          179521 Horm Res 1982;16:329–337
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 9
          Autoimmunity and Endocrine Diseases


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