Marion Gruffaz: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Tinghe Zhang: Role: Formal analysisRole: InvestigationRole: MethodologyRole: SoftwareRole: ValidationRole:
VisualizationRole: Writing – review & editing
Vickie Marshall: Role: Data curationRole: InvestigationRole: MethodologyRole: Writing – review & editing
Priscila Gonçalves: Role: Data curationRole: InvestigationRole: MethodologyRole: Writing – review & editing
Ramya Ramaswami: Role: Data curationRole: InvestigationRole: MethodologyRole: Writing – review & editing
Nazzarena Labo: Role: Data curationRole: InvestigationRole: MethodologyRole: Writing – review & editing
Denise Whitby: Role: Funding acquisitionRole: InvestigationRole: Project administrationRole: ResourcesRole:
SupervisionRole: ValidationRole: Writing – review & editing
Thomas S. Uldrick: Role: InvestigationRole: SupervisionRole: Writing – review & editing
Robert Yarchoan: Role: Funding acquisitionRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: Writing – review & editing
Yufei Huang: Role: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole:
ResourcesRole: SoftwareRole: SupervisionRole: ValidationRole: Writing – review & editing
Shou-Jiang Gao:
ORCID: http://orcid.org/0000-0001-6194-1742
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: SupervisionRole: ValidationRole: Writing – original draftRole: Writing
– review & editing
Yan Yuan: Role: Editor
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
17
January
2020
Publication date Collection:
January
2020
Volume: 16
Issue: 1
Electronic Location Identifier: e1008114
Affiliations
[1
]
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University
of Southern California, Los Angeles, United States of America
[2
]
Department of Electrical and Computer Engineering, University of Texas at San Antonio,
San Antonio, Texas, United States of America
[3
]
Viral Oncology Section, AIDS and Cancer Virus Program, Leidos Biomedical Research
Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United
States of America
[4
]
HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute,
Bethesda, Maryland, United States of America
[5
]
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
[6
]
Department of Epidemiology and Biostatistics, The University of Texas Health San Antonio,
San Antonio, Texas, United States of America
[7
]
UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University
of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
University of Pennsylvania, UNITED STATES
Author notes
I have read the journal’s policy and the authors of this manuscript have the following
competing interests: TSU and RY are co-inventors on a patent related to the treatment
of KSHV-associated diseases with immune modulatory compounds, and the spouse of RY
is a co-inventor on a patent related to the measurement of KSHV vIL-6. These inventions
were all made as part of their duties as employees of the U.S. Government, and the
patents are or will be assigned to U.S. Department of Health and Human Services. The
government may convey a portion of the royalties it receives from licensure of its
patents to its employee inventors. RY and TSU have a CRADA with Celgene Corp. and
recently conducted clinical research using drugs supplied to the NCI by Merck and
Co., Hoffman LaRoche, and Bayer Healthcare. TSU receives additional research funding
from Roche. None of the other co-authors have conflicts of interest to disclose.
[¤]
Current address: Center for Novel Cancer Therapies, Monter Cancer Center, Lake Success,
New York, United States of America
Author information
Article
Publisher ID:
PPATHOGENS-D-19-01331
DOI: 10.1371/journal.ppat.1008114
PMC ID: 6992226
PubMed ID: 31951641
SO-VID: 26b8f9d7-ae18-47a7-b2d6-3a0fba0f7937
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
Funded by: National Cancer Institute (US)
Award ID: CA096512
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6194-1742
Shou-Jiang Gao
Funded by: NCI
Award ID: CA124332
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6194-1742
Shou-Jiang Gao
Funded by: NCI
Award ID: CA132637
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6194-1742
Shou-Jiang Gao
Funded by: NCI
Award ID: CA177377
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6194-1742
Shou-Jiang Gao
Funded by: NCI
Award ID: CA213275
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6194-1742
Shou-Jiang Gao
Funded by: NCI
Award ID: CA197153
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6194-1742
Shou-Jiang Gao
Funded by: funder-id http://dx.doi.org/10.13039/100000072, National Institute of Dental and Craniofacial Research;
Award ID: DE025465
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6194-1742
Shou-Jiang Gao
Funded by: NCI
Award ID: HHSN261200800001E
Award Recipient
:
Denise Whitby
Funded by: NCI
Award ID: Intramural Research Program
Award Recipient
:
Robert Yarchoan
This work was in part supported by grants from NIH (DE025465, CA096512, CA124332,
CA132637, CA177377, CA213275 and CA197153) to S-J Gao, and in part by the Intramural
Research Program of the National Cancer Institute, NIH and by US federal funds from
the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E.
The funders had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbiome
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Microbial Genomics
Subject:
Microbiome
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Microbial Genomics
Subject:
Microbiome
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Sarcomas
Subject:
Kaposi Sarcoma
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
DNA viruses
Subject:
Herpesviruses
Subject:
Kaposi's Sarcoma-Associated Herpesvirus
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Herpesviruses
Subject:
Kaposi's Sarcoma-Associated Herpesvirus
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Herpesviruses
Subject:
Kaposi's Sarcoma-Associated Herpesvirus
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Herpesviruses
Subject:
Kaposi's Sarcoma-Associated Herpesvirus
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Ecology
Subject:
Ecological Metrics
Subject:
Species Diversity
Subject:
Ecology and Environmental Sciences
Subject:
Ecology
Subject:
Ecological Metrics
Subject:
Species Diversity
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Biology and Life Sciences
Subject:
Taxonomy
Subject:
Microbial Taxonomy
Subject:
Computer and Information Sciences
Subject:
Data Management
Subject:
Taxonomy
Subject:
Microbial Taxonomy
