LHRH Test in the Assessment of Puberty in Normal Children

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Abstract

We compared the performance of a sensitive immunoradiometric assay for luteinizing hormone (LH) with a standard radioimmunoassay and assessed the utility of a single LH determination after a standard dose of LH-releasing hormone (LHRH) in distinguishing pubertal from prepubertal state. Nocturnal integrated LH concentration and LH response to a standard LHRH test were assessed in 56 normal children aged 6-17 years. For each assay we examined sensitivities at fixed specificities and areas under the receiver-operator characteristic curves. The results show that: (1) the immunoradiometric assay exhibits better test performance; (2) a single blood sample 30, 45, or 60 min after LHRH administration is as useful to distinguish pubertal from prepubertal state in normal children as the peak LH estimated by multiple blood sampling, and (3) a single cutoff level for IRMA LH can be applied to these time points.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1994

Publication date (Print): 1994

Publication date (Electronic): 05 December 2008

Volume: 41

Issue: 1

Pages: 10-15

Affiliations

Departments of Pediatrics, Bradley Hospital, Brown University, and Health Care Policy, Harvard Medical School, Cambridge, Mass., USA

Article

Publisher ID: 183870 Other ID: Horm Res 1994;41:10–15

DOI: 10.1159/000183870

PubMed ID: 8013936

SO-VID: 26c645e7-afd0-4444-b7af-ce93c0b0a9a7

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 27 January 1993

Date accepted : 22 October 1993

Page count

Pages: 6

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