2
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      The Impact of Lifetime Alcohol and Cigarette Smoking Loads on Amyotrophic Lateral Sclerosis Progression: A Cross-Sectional Study

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background—Amyotrophic lateral sclerosis (ALS) is a devastating and untreatable motor neuron disease; smoking and alcohol drinking may impact its progression rate. Objective—To ascertain the influence of smoking and alcohol consumption on ALS progression rates. Methods—Cross-sectional multicenter study, including 241 consecutive patients (145 males); mean age at onset was 59.9 ± 11.8 years. Cigarette smoking and alcohol consumption data were collected at recruitment through a validated questionnaire. Patients were categorized into three groups according to ΔFS (derived from the ALS Functional Rating Scale-Revised and disease duration from onset): slow ( n = 81), intermediate (80), and fast progressors (80). Results—Current smokers accounted for 44 (18.3%) of the participants, former smokers accounted for 10 (4.1%), and non-smokers accounted for 187 (77.6%). The age of ALS onset was lower in current smokers than non-smokers, and the ΔFS was slightly, although not significantly, higher for smokers of >14 cigarettes/day. Current alcohol drinkers accounted for 147 (61.0%) of the participants, former drinkers accounted for 5 (2.1%), and non-drinkers accounted for 89 (36.9%). The log(ΔFS) was weakly correlated only with the duration of alcohol consumption ( p = 0.028), but not with the mean number of drinks/day or the drink-years. Conclusions: This cross-sectional multicenter study suggested a possible minor role for smoking in worsening disease progression. A possible interaction with alcohol drinking was suggested.

          Related collections

          Most cited references37

          • Record: found
          • Abstract: not found
          • Article: not found

          The Measurement of Observer Agreement for Categorical Data

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.

            Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalisability. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) initiative developed recommendations on what should be included in an accurate and complete report of an observational study. We defined the scope of the recommendations to cover three main study designs: cohort, case-control, and cross-sectional studies. We convened a 2-day workshop in September, 2004, with methodologists, researchers, and journal editors to draft a checklist of items. This list was subsequently revised during several meetings of the coordinating group and in e-mail discussions with the larger group of STROBE contributors, taking into account empirical evidence and methodological considerations. The workshop and the subsequent iterative process of consultation and revision resulted in a checklist of 22 items (the STROBE statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.18 items are common to all three study designs and four are specific for cohort, case-control, or cross-sectional studies.A detailed explanation and elaboration document is published separately and is freely available on the websites of PLoS Medicine, Annals of Internal Medicine, and Epidemiology. We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              The intraclass correlation coefficient as a measure of reliability.

              J J Bartko (1966)
                Bookmark

                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Life (Basel)
                Life (Basel)
                life
                Life
                MDPI
                2075-1729
                17 April 2021
                April 2021
                : 11
                : 4
                : 352
                Affiliations
                [1 ]Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy; aliona.cucovici@ 123456unifg.it
                [2 ]Neurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy; a.ivashynka@ 123456operapadrepio.it (A.I.); valerenna87@ 123456gmail.com (V.R.); m.zarrelli@ 123456operapadrepio.it (M.Z.)
                [3 ]Unit of Biostatistics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy; a.fontana@ 123456operapadrepio.it (A.F.); m.copetti@ 123456operapadrepio.it (M.C.)
                [4 ]Department of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy
                [5 ]ICT Innovation & Research Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy; s.russo@ 123456operapadrepio.it
                [6 ]Department of Neurology and ALS Centre, University of Piemonte Orientale, Maggiore della Carità Hospital, 28100 Novara, Italy; letizia.mazzini@ 123456uniupo.it (L.M.); ileanagagliardi91@ 123456gmail.com (I.G.)
                [7 ]Neurology Unit, Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41125 Modena, Italy; mandrioli.jessica@ 123456aou.mo.it (J.M.); martinelli.ilaria88@ 123456gmail.com (I.M.)
                [8 ]Department of Neurology, State University of Medicine and Pharmacy “Nicolae Testemitanu”, 2004 Chisinau, Moldova; lisnicv@ 123456yahoo.com
                [9 ]Department of Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania and “RoNeuro” Institute for Neurological Research and Diagnostic, 400000 Cluj-Napoca, Romania; office@ 123456ssnn.ro
                Author notes
                Author information
                https://orcid.org/0000-0003-3412-0628
                https://orcid.org/0000-0003-0840-1872
                https://orcid.org/0000-0002-8773-8651
                https://orcid.org/0000-0002-9244-9782
                https://orcid.org/0000-0003-2566-3671
                https://orcid.org/0000-0002-5432-8859
                https://orcid.org/0000-0002-6339-5738
                Article
                life-11-00352
                10.3390/life11040352
                8072690
                26cc0d20-31d8-40b6-9ca2-4d82bdb03aff
                © 2021 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                History
                : 13 February 2021
                : 13 April 2021
                Categories
                Article

                amyotrophic lateral sclerosis,smoking,alcohol drinking,disease progression rate,prognosis,questionnaire

                Comments

                Comment on this article