54
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Automated diagnosis of diabetic retinopathy and glaucoma using fundus and OCT images

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We describe a system for the automated diagnosis of diabetic retinopathy and glaucoma using fundus and optical coherence tomography (OCT) images. Automatic screening will help the doctors to quickly identify the condition of the patient in a more accurate way. The macular abnormalities caused due to diabetic retinopathy can be detected by applying morphological operations, filters and thresholds on the fundus images of the patient. Early detection of glaucoma is done by estimating the Retinal Nerve Fiber Layer (RNFL) thickness from the OCT images of the patient. The RNFL thickness estimation involves the use of active contours based deformable snake algorithm for segmentation of the anterior and posterior boundaries of the retinal nerve fiber layer. The algorithm was tested on a set of 89 fundus images of which 85 were found to have at least mild retinopathy and OCT images of 31 patients out of which 13 were found to be glaucomatous. The accuracy for optical disk detection is found to be 97.75%. The proposed system therefore is accurate, reliable and robust and can be realized.

          Related collections

          Most cited references33

          • Record: found
          • Abstract: found
          • Article: not found

          Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response.

          We describe an automated method to locate and outline blood vessels in images of the ocular fundus. Such a tool should prove useful to eye care specialists for purposes of patient screening, treatment evaluation, and clinical study. Our method differs from previously known methods in that it uses local and global vessel features cooperatively to segment the vessel network. We evaluate our method using hand-labeled ground truth segmentations of 20 images. A plot of the operating characteristic shows that our method reduces false positives by as much as 15 times over basic thresholding of a matched filter response (MFR), at up to a 75% true positive rate. For a baseline, we also compared the ground truth against a second hand-labeling, yielding a 90% true positive and a 4% false positive detection rate, on average. These numbers suggest there is still room for a 15% true positive rate improvement, with the same false positive rate, over our method. We are making all our images and hand labelings publicly available for interested researchers to use in evaluating related methods.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            In vivo human retinal imaging by Fourier domain optical coherence tomography.

            We present what is to our knowledge the first in vivo tomograms of human retina obtained by Fourier domain optical coherence tomography. We would like to show that this technique might be as powerful as other optical coherence tomography techniques in the ophthalmologic imaging field. The method, experimental setup, data processing, and images are discussed.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Prevalence of diabetic retinopathy in India: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study report 2.

              The aim of the study was to estimate the prevalence of diabetic retinopathy in an urban Indian population older than 40 years. A population-based cross-sectional study. Five thousand nine hundred ninety-nine subjects residing in Chennai, India, were enumerated. A multistage random sampling, based on socioeconomic criteria, was followed. Identified subjects with diabetes mellitus (based on the World Health Organization criteria) underwent detailed examination at the base hospital. The fundi of all patients were photographed using 45 degrees , 4-field stereoscopic digital photography. The diagnosis of diabetic retinopathy was based on Klein's classification of the Early Treatment Diabetic Retinopathy Study scale. These included age- and gender-adjusted prevalence of diabetes and diabetic retinopathy, and correlation of prevalence with history-based risk factors. The age- and gender-adjusted prevalence rate of diabetes in an urban Chennai population was 28.2% (95% confidence interval [CI], 27.0-29.3), and the prevalence of diabetic retinopathy in general population was 3.5% (95% CI, 3.49-3.54). The prevalence of diabetic retinopathy in the population with diabetes mellitus was 18.0% (95% CI, 16.0-20.1). History-based variables that were significantly associated with increased risk of diabetic retinopathy included gender (men at greater risk; odds ratio [OR], 1.41; 95% CI, 1.04-1.91); use of insulin (OR, 3.52; 95% CI, 2.05-6.02); longer duration of diabetes (>15 years; OR, 6.43; 95% CI, 3.18-12.90); and subjects with known diabetes mellitus (OR, 2.98; 95% CI, 1.72-5.17). Differences in the socioeconomic status did not influence the occurrence of diabetic retinopathy. The prevalence of diabetic retinopathy was 18% in an urban population with diabetes mellitus in India. The duration of diabetes is the strongest predictor for diabetic retinopathy. The author(s) have no proprietary or commercial interest in any materials discussed in this article.
                Bookmark

                Author and article information

                Journal
                Lipids Health Dis
                Lipids Health Dis
                Lipids in Health and Disease
                BioMed Central
                1476-511X
                2012
                13 June 2012
                : 11
                : 73
                Affiliations
                [1 ]School of Electronics Engineering, VIT University, Vellore, 632014, Tamil Nadu, India
                [2 ]Jawaharlal Nehru Technological University, Kakinada, 533 003, India
                [3 ]UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH, 44120, USA
                [4 ]Military Hospital, Pune, 411 040, India
                [5 ]GVP-SIRC, GVPCE Campus, Madhurawada, Visakhapatnam, 530048, India
                Article
                1476-511X-11-73
                10.1186/1476-511X-11-73
                3477058
                22695250
                26cc4471-4fe3-43d1-8463-61cbc34f6d01
                Copyright ©2012 Pachiyappan et al.; licensee BioMed Central Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 23 April 2012
                : 11 May 2012
                Categories
                Research

                Biochemistry
                rnfl,glaucoma,fundus image,image processing,oct,diabetic retinopathy
                Biochemistry
                rnfl, glaucoma, fundus image, image processing, oct, diabetic retinopathy

                Comments

                Comment on this article