18
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Protective role of interleukin-10 in atherosclerosis.

      Circulation Research
      Animals, Arteriosclerosis, immunology, pathology, therapy, Cholesterol, blood, Diet, Atherogenic, Female, Interleukin-10, deficiency, therapeutic use, Mice, Mice, Inbred C57BL

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The potential role of anti-inflammatory cytokines in the modulation of the atherosclerotic process remains unknown. Interleukin (IL)-10 has potent deactivating properties in macrophages and T cells and modulates many cellular processes that may interfere with the development and stability of the atherosclerotic plaque. IL-10 is expressed in human atherosclerosis and is associated with decreased signs of inflammation. In the present study, we show that IL-10-deficient C57BL/6J mice fed an atherogenic diet and raised under specific pathogen-free conditions exhibit a significant 3-fold increase in lipid accumulation compared with wild-type mice. Interestingly, the susceptibility of IL-10-deficient mice to atherosclerosis was exceedingly high (30-fold increase) when the mice were housed under conventional conditions. Atherosclerotic lesions of IL-10-deficient mice showed increased T-cell infiltration, abundant interferon-gamma expression, and decreased collagen content. In vivo, transfer of murine IL-10 achieved 60% reduction in lesion size. These results underscore the critical roles of IL-10 in both atherosclerotic lesion formation and stability. Moreover, IL-10 appears to be crucial as a protective factor against the effect of environmental pathogens on atherosclerosis.

          Related collections

          Author and article information

          Journal
          10521249
          10.1161/01.RES.85.8.e17

          Chemistry
          Animals,Arteriosclerosis,immunology,pathology,therapy,Cholesterol,blood,Diet, Atherogenic,Female,Interleukin-10,deficiency,therapeutic use,Mice,Mice, Inbred C57BL

          Comments

          Comment on this article