We present a thermodynamic framework for the refined weak coupling limit. In this limit the interaction between system and environment is weak, but not negligible. As a result, the system dynamics becomes non-Markovian breaking divisibility conditions. Nevertheless, we propose a derivation of the first and second law just in terms of the reduced system dynamics. To this end, we extend the refined weak coupling limit for allowing slow-varying external drivings, and reconsider the definition of internal energy due to the non-negligible interaction.