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      Serum IgA/C3 Ratio May Predict Diagnosis and Prognostic Grading in Patients with IgA Nephropathy

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          Recently, the authors reported that the ratio of serum IgA to C3 (serum IgA/C3 ratio) is a good marker to distinguish patients with IgA nephropathy from non-IgA nephropathy patients together with serum IgA levels using an international reference preparation (IFCC/CRM470). In this study, the authors investigated whether the serum IgA/C3 ratio might be an indicator of prognostic grading in patients with IgA nephropathy. Two hundred and thirteen patients with IgA nephropathy and 96 other glomerular diseases including diffuse or focal mesangial proliferative glomerulonephritis without mesangial IgA deposition (non-IgA PGN), membranous nephropathy and thin basement membrane syndrome were examined. The levels of serum IgA and C3 in these patients were adjusted by the specified formula to those using international standard serum (IFCC/CRM470) in this study. The results of this study showed the highest levels of IgA/C3 ratio in patients with IgA nephropathy. The serum IgA/C3 ratio appears to gradually increase according to the prognostic grading of this disease. Therefore, measurement of the serum IgA/C3 ratio may be useful for prediction of diagnosis and prognostic grading in patients with IgA nephropathy.

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          Serum protein standardization project in Japan: Evaluation of an IFCC reference material (RPPHS/CRM470) and establishment of reference intervals

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            Measurement of serum IgA and C3 may predict the diagnosis of patients with IgA nephropathy prior to renal biopsy


              Author and article information

              S. Karger AG
              August 2002
              15 July 2002
              : 91
              : 4
              : 755-758
              Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
              65043 Nephron 2002;91:755–758
              © 2002 S. Karger AG, Basel

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              Page count
              Tables: 2, References: 10, Pages: 4
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/65043
              Short Communication

              Cardiovascular Medicine, Nephrology

              IgA nephropathy, Serum IgA/C3 ratio, Diagnosis, Prognosis


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