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      Detection of Glycosylated Protein in Renal Tissues and Dermal Vascular Vessels in the Microalbuminuric Stage of Diabetic Nephropathy Using the Nitro Blue Tetrazolium Reaction

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          Detection of glycosylated protein in renal and dermal tissues was performed in patients in the microalbuminuric stage of diabetic nephropathy using the nitro blue tetrazolium (NBT) reaction. The intensity of NBT staining in glomeruli and dermal vascular vessels was marked in the microalbuminuric stage as well as in the overtly proteinuric stage. The NBT staining in the renal and dermal vascular walls in both stages was significantly stronger than in the samples of control autopsy patients. It appeared that nonenzymatic glycosylation in various tissues, i.e. kidneys and dermal vascular vessels, had already progressed in the microalbuminuric stage in patients with diabetic nephropathy.

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          Author and article information

          S. Karger AG
          17 December 2008
          : 68
          : 2
          : 207-211
          aDivision of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, bDepartment of Medicine and cDepartment of Dermatology, Juntendo Urayasu Hospital, Urayasu City, Chiba, Japan
          188258 Nephron 1994;68:207–211
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 5
          Original Paper

          Cardiovascular Medicine, Nephrology

          NIDDM, Glycosylation, Vessels, NBT reaction


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