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Neural circuits underlying the pathophysiology of mood disorders
Author(s):
Joseph L. Price
,
Wayne C. Drevets
Publication date
Created:
January 2012
Publication date
(Print):
January 2012
Journal:
Trends in Cognitive Sciences
Publisher:
Elsevier BV
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Abstract
Although mood disorders constitute leading causes of disability, until recently little was known about their pathogenesis. The delineation of anatomical networks that support emotional behavior (mainly derived from animal studies) and the development of neuroimaging technologies that allow in vivo characterization of anatomy, physiology, and neurochemistry in human subjects with mood disorders have enabled significant advances towards elucidating the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). In this review, we integrate insights from human and animal studies, which collectively suggest that MDD and BD involve dysfunction within an extended network including the medial prefrontal cortex and anatomically-related limbic, striatal, thalamic and basal forebrain structures. Copyright © 2011 Elsevier Ltd. All rights reserved.
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Journal
Title:
Trends in Cognitive Sciences
Abbreviated Title:
Trends in Cognitive Sciences
Publisher:
Elsevier BV
ISSN (Print):
13646613
Publication date Created:
January 2012
Publication date (Print):
January 2012
Volume
: 16
Issue
: 1
Pages
: 61-71
Article
DOI:
10.1016/j.tics.2011.12.011
PubMed ID:
22197477
SO-VID:
271a877d-8f14-4e1b-b0d9-2bc16d6c77ec
Copyright ©
© 2012
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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