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Abstract
Randomized clinical trials that compare two treatments on a continuous outcome can
be analyzed using analysis of covariance (ANCOVA) or a t-test approach. We present
a method for the sample size calculation when ANCOVA is used.
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Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical
Centre, Geert Grooteplein 21, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands. G.Borm@epid.umcn.nl