Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Many studies have supported a genetic etiology for autism. Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism.

Related collections

Author and article information

Journal

PubMed ID:: 12669065

PMC ID:: 1925054

DOI:: 10.1038/ng1136

Data availability:

Comments

Comment on this article

scite_

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.

Read this article at

Genes & Diseases

Journal

Comment on this article