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Inhibition of extracellular nucleotides hydrolysis intensifies the allergic bronchospasm. A novel protective role of ectonucleotidases.
J Chávez
1 ,
M H Vargas ,
D C Rebollar-Ayala ,
V Díaz-Hernández ,
J E Cruz-Valderrama ,
E Flores-Soto ,
M Flores-García ,
N N Jiménez-Vargas ,
C Barajas-López ,
L M Montaño
Apr 2013
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Abstract
Nucleotides released to the extracellular space stimulate purinergic receptors, and their effects are modulated by ectonucleotidases. The role of ATP in the allergic bronchospasm has been scantly studied.