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      18F-FDG PET/CT for early prediction of response to neoadjuvant lapatinib, trastuzumab, and their combination in HER2-positive breast cancer: results from Neo-ALTTO.

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          Abstract

          Molecular imaging receives increased attention for selecting patients who will benefit from targeted anticancer therapies. Neo-ALTTO (Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation) enrolled 455 women with invasive human epidermal growth factor receptor 2 (HER2)-positive breast cancer and compared rates of pathologic complete response (pCR) to neoadjuvant lapatinib, trastuzumab, and their combination. Each anti-HER2 therapy was given alone for 6 wk, followed by 12 wk of the same therapy plus weekly paclitaxel. The early metabolic effects of the anti-HER2 therapies on the primary tumors and their predictive values for pCR were assessed in a subset of patients.

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          Author and article information

          Journal
          J. Nucl. Med.
          Journal of nuclear medicine : official publication, Society of Nuclear Medicine
          1535-5667
          0161-5505
          Nov 2013
          : 54
          : 11
          Affiliations
          [1 ] Nuclear Medicine Department, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
          Article
          jnumed.112.119271
          10.2967/jnumed.112.119271
          24092940
          274743a1-2c6d-4487-955a-85a9adee934e
          History

          18F-FDG-PET/CT,anti-HER2 drugs,early response assessment

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