Targeting of the C-Jun/BCL-XL/P21 Axis Accelerates the Switch from Senescence to Apoptosis Upon ROC1 Knockdown in Gastric Cancer Cells.

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Abstract

Regulator of cullins-1 (ROC1) is a pivotal component of cullin-RING E3 ubiquitin ligases, which help to regulate distinct cellular processes by governing the degradation of various substrates. Because the role of ROC1 in gastric cancer is largely uncharacterized, we investigated the relationship between ROC1 expression and the prognosis of gastric cancer patients and explored the biological function of ROC1 and its underlying mechanisms in gastric cancer.

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Author and article information

Journal

Journal ID (iso-abbrev): Cell. Physiol. Biochem.

Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Publisher: S. Karger AG

ISSN (Electronic): 1421-9778

ISSN (Print): 1015-8987

Publication date (Electronic): 2018

Volume: 48

Issue: 3

Affiliations

[1 ] Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, China.

[2 ] Institute of Biomedical Science of Shanghai Medical School, Fudan University, Shanghai, China.

[3 ] The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Article

Publisher Item ID: 000491979

DOI: 10.1159/000491979

PubMed ID: 30041196

SO-VID: 27486285-e6f4-40ae-bd63-0b1eeb7138ac

History

Keywords: P21,Apoptosis,BCL-XL,C-Jun,Senescence,ROC1,Gastric cancer

Data availability:

Keywords: P21, Apoptosis, BCL-XL, C-Jun, Senescence, ROC1, Gastric cancer

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