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Circulating anti-β2-glycoprotein I antibodies of peripheral arterial disease patients trigger a genomic overexpression of Toll-like receptor 4 in endothelial cells.

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      Abstract

      Circulating anti-β2-glycoprotein I (ABGPI) antibodies are associated with peripheral arterial disease (PAD) and induce the expression of leukocyte adhesion molecules and proinflammatory cytokines by endothelial cells. Our aim is to study a transcriptional activation pathway of the innate immune system through the cellular signalling cascade triggered by receptors Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) of endothelial cells after the exposure of these cells to seropositive ABGPI human serum obtained from PAD patients.

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      Affiliations
      [1 ] Department of Angiology and Vascular Surgery, Hospital Universitario de Getafe, Madrid, Spain. Electronic address: varelot@hotmail.com.
      [2 ] Department of Angiology and Vascular Surgery, Hospital Universitario de Getafe, Madrid, Spain.
      [3 ] Department of Research, Hospital Universitario de Getafe, Madrid, Spain.
      Journal
      J. Vasc. Surg.
      Journal of vascular surgery
      1097-6809
      0741-5214
      Apr 2015
      : 61
      : 4
      24472415
      S0741-5214(13)02161-7
      10.1016/j.jvs.2013.11.066
      Copyright © 2015 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

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