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Circulating anti-β2-glycoprotein I (ABGPI) antibodies are associated with peripheral
arterial disease (PAD) and induce the expression of leukocyte adhesion molecules and
proinflammatory cytokines by endothelial cells. Our aim is to study a transcriptional
activation pathway of the innate immune system through the cellular signalling cascade
triggered by receptors Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4)
of endothelial cells after the exposure of these cells to seropositive ABGPI human
serum obtained from PAD patients.