Gender affects acute organ toxicity during radiochemotherapy for rectal cancer: long-term results of the German CAO/ARO/AIO-94 phase III trial.

Wolff, Hendrik Andreas; Conradi, Lena-Christin; Beissbarth, Tim; Leha, Andreas; Hohenberger, Werner; Merkel, Susanne; Fietkau, Rainer; Raab, Hans Rudolf; Tschmelitsch, Jörg; Hess, Clemens Friedrich; Becker, Heinz; Wittekind, Christian; Sauer, Rolf; Rödel, Claus; Liersch, Torsten

doi:10.1016/j.radonc.2013.05.009

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Gender affects acute organ toxicity during radiochemotherapy for rectal cancer: long-term results of the German CAO/ARO/AIO-94 phase III trial.

Author(s): Hendrik Andreas Wolff ¹ , Lena-Christin Conradi , Tim Beissbarth , Andreas Leha , Werner Hohenberger , Susanne Merkel , Rainer Fietkau , Hans-Rudolf Raab , Jörg Tschmelitsch , Clemens Friedrich Hess , Heinz Becker , Christian Wittekind , Rolf Sauer , Claus Rödel , Torsten Liersch

Publication date (Electronic): Jul 2013

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Keywords: Gender, Multimodal treatment, Radiochemotherapy, Rectal cancer, Treatment associated toxicity

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Abstract

The CAO/ARO/AIO-94 phase-III-trial demonstrated a significant improvement of preoperative chemoradiotherapy (CRT) versus postoperative CRT on local control for UICC stage II/III rectal cancer patients, but no effect on long-term survival. In this add-on evaluation, we investigated the association of gender and age with acute toxicity and outcome.

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Journal ID (iso-abbrev): Radiother Oncol

Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

ISSN (Electronic): 1879-0887

ISSN (Print): 0167-8140

Publication date (Electronic): Jul 2013

Volume: 108

Issue: 1

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[1 ] Department of Radiotherapy, University Medical Center Göttingen, Germany.

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Publisher Item ID: S0167-8140(13)00221-1

DOI: 10.1016/j.radonc.2013.05.009

PubMed ID: 23768685

SO-VID: 2753ceee-dd8c-45a1-b904-f9af28ac03c4

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Keywords: Gender,Multimodal treatment,Radiochemotherapy,Rectal cancer,Treatment associated toxicity

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Keywords: Gender, Multimodal treatment, Radiochemotherapy, Rectal cancer, Treatment associated toxicity

Gender affects acute organ toxicity during radiochemotherapy for rectal cancer: long-term results of the German CAO/ARO/AIO-94 phase III trial.

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SDG 5: Gender Equality

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