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Multidrug resistance in cancer: role of ATP-dependent transporters.

Nature reviews. Cancer

pharmacokinetics, adverse effects, Xenobiotics, Structure-Activity Relationship, Permeability, physiology, genetics, antagonists & inhibitors, P-Glycoprotein, Organ Specificity, metabolism, drug therapy, Neoplasms, Neoplasm Proteins, Multigene Family, classification, chemistry, Multidrug Resistance-Associated Proteins, Leukemia, Humans, Forecasting, Female, Drug Resistance, Neoplasm, Drug Resistance, Multiple, Drug Design, Breast Neoplasms, Biological Markers, Antineoplastic Agents, Adenosine Triphosphate, ATP-Binding Cassette Transporters

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      Chemotherapeutics are the most effective treatment for metastatic tumours. However, the ability of cancer cells to become simultaneously resistant to different drugs--a trait known as multidrug resistance--remains a significant impediment to successful chemotherapy. Three decades of multidrug-resistance research have identified a myriad of ways in which cancer cells can elude chemotherapy, and it has become apparent that resistance exists against every effective drug, even our newest agents. Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy.

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