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      Functional blockade of the parabrachial area by tetrodotoxin disrupts the acquisition of conditioned taste aversion induced by motion-sickness in rats

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      Neuroscience Letters
      Elsevier BV

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          Abstract

          The role of the parabrachial area in conditioned taste aversion (CTA) induced by motion-sickness was studied in male Wistar rats. In the first experiment, one-trial conditioned taste aversion, to a 0.5% decaffeinated coffee solution, was induced by 30 min of vertical rotatory motion (80 rev./min) in intact rats. In the second experiment, reversible blockade of the neural activity in various brainstem sites was induced by bilateral intracerebral injections of tetrodotoxin (TTX) (10 ng/microl) after conditioning. Blockade of the parabrachial area, but neither A8 nor lateral vestibular nucleus, disrupted the acquisition of (CTA). The results are discussed in terms of an associative role of the parabrachial area in body rotation-induced taste aversion learning, as the area was intact during sensory processing and testing.

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          Author and article information

          Journal
          Neuroscience Letters
          Neuroscience Letters
          Elsevier BV
          03043940
          April 1999
          April 1999
          : 265
          : 1
          : 57-60
          Article
          10.1016/S0304-3940(99)00209-8
          10327205
          277bf079-554d-48dc-9b3a-31400eb79cc5
          © 1999

          https://www.elsevier.com/tdm/userlicense/1.0/

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