109
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Maternal Iodine Intake and Offspring Attention-Deficit/Hyperactivity Disorder: Results from a Large Prospective Cohort Study

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Current knowledge about the relationship between mild to moderately inadequate maternal iodine intake and/or supplemental iodine on child neurodevelopment is sparse. Using information from 77,164 mother-child pairs in the Norwegian Mother and Child Cohort Study, this study explored associations between maternal iodine intake and child attention-deficit/hyperactivity disorder (ADHD) diagnosis, registered in the Norwegian Patient Registry and maternally-reported child ADHD symptoms at eight years of age. Pregnant women reported food and supplement intakes by questionnaire in gestational week 22. In total, 1725 children (2.2%) were diagnosed with ADHD. In non-users of supplemental iodine (53,360 mothers), we found no association between iodine intake from food and risk of child ADHD diagnosis ( p = 0.89), while low iodine from food (<200 µg/day) was associated with higher child ADHD symptom scores (adjusted difference in score up to 0.08 standard deviation (SD), p < 0.001, n = 19,086). In the total sample, we found no evidence of beneficial effects of maternal use of iodine-containing supplements ( n = 23,804) on child ADHD diagnosis or symptom score. Initiation of iodine supplement use in gestational weeks 0–12 was associated with an increased risk of child ADHD (both measures). In conclusion, insufficient maternal iodine intake was associated with increased child ADHD symptom scores at eight years of age, but not with ADHD diagnosis. No reduction of risk was associated with maternal iodine supplement use.

          Related collections

          Most cited references36

          • Record: found
          • Abstract: found
          • Article: not found

          ADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysis.

          Previous studies have identified significant variability in attention-deficit / hyperactivity disorder (ADHD) prevalence estimates worldwide, largely explained by methodological procedures. However, increasing rates of ADHD diagnosis and treatment throughout the past few decades have fuelled concerns about whether the true prevalence of the disorder has increased over time. We updated the two most comprehensive systematic reviews on ADHD prevalence available in the literature. Meta-regression analyses were conducted to test the effect of year of study in the context of both methodological variables that determined variability in ADHD prevalence (diagnostic criteria, impairment criterion and source of information), and the geographical location of studies. We identified 154 original studies and included 135 in the multivariate analysis. Methodological procedures investigated were significantly associated with heterogeneity of studies. Geographical location and year of study were not associated with variability in ADHD prevalence estimates. Confirming previous findings, variability in ADHD prevalence estimates is mostly explained by methodological characteristics of the studies. In the past three decades, there has been no evidence to suggest an increase in the number of children in the community who meet criteria for ADHD when standardized diagnostic procedures are followed.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical Consultation.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The thyroid-brain interaction in thyroid disorders and mood disorders.

              Thyroid hormones play a critical role in the metabolic activity of the adult brain, and neuropsychiatric manifestations of thyroid disease have long been recognised. However, it is only recently that methodology such as functional neuroimaging has been available to facilitate investigation of thyroid hormone metabolism. Although the role of thyroid hormones in the adult brain is not yet specified, it is clear that without optimal thyroid function, mood disturbance, cognitive impairment and other psychiatric symptoms can emerge. Additionally, laboratory measurements of peripheral thyroid function may not adequately characterise central thyroid metabolism. Here, we review the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders.
                Bookmark

                Author and article information

                Journal
                Nutrients
                Nutrients
                nutrients
                Nutrients
                MDPI
                2072-6643
                13 November 2017
                November 2017
                : 9
                : 11
                : 1239
                Affiliations
                [1 ]Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, 0456 Oslo, Norway; mariannehope.abel@ 123456fhi.no (M.H.A.); ida.henriette.caspersen@ 123456fhi.no (I.H.C.); hellemargrete.meltzer@ 123456fhi.no (H.M.M.)
                [2 ]Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, 0167 Oslo, Norway; liv.elin.torheim@ 123456hioa.no
                [3 ]Department of Research and Development, TINE SA, 0902 Oslo, Norway
                [4 ]Division of Mental and Physical Health, Norwegian Institute of Public Health, 0456 Oslo, Norway; eivind.ystrom@ 123456fhi.no (E.Y.); heidi.aase@ 123456fhi.no (H.A.); ragnabugge.askeland@ 123456fhi.no (R.B.A.); ted.reichborn-kjennerud@ 123456fhi.no (T.R.-K.)
                [5 ]Section of Health, Developmental and Personality Psychology, Department of Psychology, University of Oslo, 0315 Oslo, Norway
                [6 ]Pharmaco Epidemiology and Drug Safety Research Group, School of Pharmacy, University of Oslo, 0315 Oslo, Norway
                [7 ]Institute of Clinical Medicine, University of Oslo, 0315 Oslo, Norway
                Author notes
                [* ]Correspondence: annelise.brantsaeter@ 123456fhi.no ; Tel.: +47-2107-6326
                Author information
                https://orcid.org/0000-0003-4390-6171
                https://orcid.org/0000-0003-2591-8435
                https://orcid.org/0000-0002-3591-7017
                https://orcid.org/0000-0002-3161-1635
                https://orcid.org/0000-0002-7465-0634
                https://orcid.org/0000-0001-6315-7134
                Article
                nutrients-09-01239
                10.3390/nu9111239
                5707711
                29137191
                27865013-1377-41b6-ba90-d98b077c7774
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 10 October 2017
                : 08 November 2017
                Categories
                Article

                Nutrition & Dietetics
                adhd,attention-deficit/hyperactivity disorder,iodine,dietary supplements,pregnancy,neurodevelopment,norwegian mother and child cohort study,moba,norwegian patient registry

                Comments

                Comment on this article