Author(s): Lucio D'Anna , MD, Marsel M. Mesulam , MD, Michel Thiebaut de Schotten , PhD, Flavio Dell'Acqua , PhD, Declan Murphy , MD, Christina Wieneke , BA, Adam Martersteck , BS, Derin Cobia , PhD, Emily Rogalski , PhD, Marco Catani , MD
Publication date PMC-release: 12 April 2016
Publisher: Lippincott Williams & Wilkins
To determine if behavioral symptoms in patients with primary progressive aphasia (PPA) were associated with degeneration of a ventral frontotemporal network.
We used diffusion tensor imaging tractography to quantify abnormalities of the uncinate fasciculus that connects the anterior temporal lobe and the ventrolateral frontal cortex. Two additional ventral tracts were studied: the inferior fronto-occipital fasciculus and the inferior longitudinal fasciculus. We also measured cortical thickness of anterior temporal and orbitofrontal regions interconnected by these tracts. Thirty-three patients with PPA and 26 healthy controls were recruited.
In keeping with the PPA diagnosis, behavioral symptoms were distinctly less prominent than the language deficits. Although all 3 tracts had structural pathology as determined by tractography, significant correlations with scores on the Frontal Behavioral Inventory were found only for the uncinate fasciculus. Cortical atrophy of the orbitofrontal and anterior temporal lobe cortex was also correlated with these scores.
Brain, Annals of Neurology, Human Brain Mapping, Journal of Cognitive Neuroscience- Member of Editorial Board
Northwestern University, Study Coordinator, 2.8 yrs (Oct 2011 - August 2014)
1. NIDCD, DC008552, Study Coordinator, 2.8 yrs (Oct 2011 - August 2014) 2. NINDS, NS075075, Study Coordinator, 2.8 yrs (Oct 2011 - August 2014)
(1) NINDS/NIH, NS075075-01, Co-Investigator, 2012-current (2) NINR/NIH, NR014182-01, Co-Investigator, 2012-current
International Neuropsychological Society Conference 2013, speaker honorarium; Grand Rounds presentations 2013, 2014, 2015.
This project was supported by DC008552 from the National Institute on Deafness and Communication Disorders; AG13854 (Alzheimer Disease Core Center) from the National Institute on Aging; NS075075 from the National Institute of Neurological Disorders and Stroke (NINDS).
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. The Article Processing Charge was paid by Wellcome Trust.
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