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      Measuring Cell Mechanics

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      Colloquium Series on Quantitative Cell Biology
      Morgan & Claypool Publishers LLC

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          Atomic Force Microscope

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            Tensional homeostasis and the malignant phenotype.

            Tumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins are mechanotransducers that regulate cell fate, we asked whether tissue stiffness could promote malignant behavior by modulating integrins. We found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation. Matrix stiffness perturbs epithelial morphogenesis by clustering integrins to enhance ERK activation and increase ROCK-generated contractility and focal adhesions. Contractile, EGF-transformed epithelia with elevated ERK and Rho activity could be phenotypically reverted to tissues lacking focal adhesions if Rho-generated contractility or ERK activity was decreased. Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype.
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              Observation of a single-beam gradient force optical trap for dielectric particles

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                Author and article information

                Journal
                Colloquium Series on Quantitative Cell Biology
                Colloquium Series on Quantitative Cell Biology
                Morgan & Claypool Publishers LLC
                2375-7744
                2375-7752
                September 2015
                September 2015
                : 2
                : 1
                : 1-75
                Article
                10.4199/C00137ED1V01Y201508QCB003
                27937d5b-8fd9-4c71-b7f5-1413893a4710
                © 2015

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