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      Unaltered Distribution of Cardiac Output in the Conscious Young Spontaneously Hypertensive Rat: Evidence for Uniform Elevation of Regional Vascular Resistances

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          Radioactive microspheres (50 µmdiameter) were injected into the left ventricle of conscious rats fasted for 12 h, and the percent distribution of cardiac output to major organs was determined in young female (8–9 weeks of age) spontaneously hypertensive rats (SHR) and in age- and sex-matched Wistar Kyoto (WKY) normotensive controls. Systolic arterial blood pressure was elevated (p < 0.001) in the unanesthetized SHR (140 ± 4) compared to the WKY (112 ± 3). There was no significant difference in the percent distribution of cardiac output to the kidneys, heart, stomach, small and large intestines, liver, lungs, adrenals and limbs between the SHR and WKY. The data suggest that early in the development of high blood pressure, a uniform rise in vascular resistance exists throughout the peripheral circulation of the young SHR.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 11
          : 5-6
          : 287-294
          Department of Pharmacology, University of Georgia School of Pharmacy, Athens, Ga.
          158022 Blood Vessels 1974;11:287–294
          © 1974 S. Karger AG, Basel

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          Pages: 8
          Research Paper


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