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      Unaltered Distribution of Cardiac Output in the Conscious Young Spontaneously Hypertensive Rat: Evidence for Uniform Elevation of Regional Vascular Resistances

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          Abstract

          Radioactive microspheres (50 µmdiameter) were injected into the left ventricle of conscious rats fasted for 12 h, and the percent distribution of cardiac output to major organs was determined in young female (8–9 weeks of age) spontaneously hypertensive rats (SHR) and in age- and sex-matched Wistar Kyoto (WKY) normotensive controls. Systolic arterial blood pressure was elevated (p < 0.001) in the unanesthetized SHR (140 ± 4) compared to the WKY (112 ± 3). There was no significant difference in the percent distribution of cardiac output to the kidneys, heart, stomach, small and large intestines, liver, lungs, adrenals and limbs between the SHR and WKY. The data suggest that early in the development of high blood pressure, a uniform rise in vascular resistance exists throughout the peripheral circulation of the young SHR.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1974
          1974
          18 September 2008
          : 11
          : 5-6
          : 287-294
          Affiliations
          Department of Pharmacology, University of Georgia School of Pharmacy, Athens, Ga.
          Article
          158022 Blood Vessels 1974;11:287–294
          10.1159/000158022
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Research Paper

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