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      Preparation of core–shell Fe3O4@poly(dopamine) magnetic nanoparticles for biosensor construction

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          Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy.

          At present, nanoparticles are used for various biomedical applications where they facilitate laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the use of nanoparticles is attracting increasing attention due to their unique capabilities and their negligible side effects not only in cancer therapy but also in the treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with proper surface architecture and conjugated targeting ligands/proteins have attracted a great deal of attention for drug delivery applications. This review covers recent advances in the development of SPIONs together with their possibilities and limitations from fabrication to application in drug delivery. In addition, the state-of-the-art synthetic routes and surface modification of desired SPIONs for drug delivery purposes are described. Copyright © 2010 Elsevier B.V. All rights reserved.
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            Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.

            Magnetic nanoparticles (MNPs) represent a class of non-invasive imaging agents that have been developed for magnetic resonance (MR) imaging. These MNPs have traditionally been used for disease imaging via passive targeting, but recent advances have opened the door to cellular-specific targeting, drug delivery, and multi-modal imaging by these nanoparticles. As more elaborate MNPs are envisioned, adherence to proper design criteria (e.g. size, coating, molecular functionalization) becomes even more essential. This review summarizes the design parameters that affect MNP performance in vivo, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers. A careful review of the chemistries used to modify the surfaces of MNPs is also given, with attention paid to optimizing the activity of bound ligands while maintaining favorable physicochemical properties. Copyright 2009 Elsevier B.V. All rights reserved.
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              Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings.

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                Author and article information

                Journal
                JMCBDV
                J. Mater. Chem. B
                J. Mater. Chem. B
                Royal Society of Chemistry (RSC)
                2050-750X
                2050-7518
                2014
                2014
                : 2
                : 6
                : 739-746
                Article
                10.1039/C3TB21171A
                32261292
                279d67b5-f243-4394-b840-2919d56334ce
                © 2014
                History

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