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Neuronal differentiation of cultured human NTERA-2cl.D1 cells leads to increased expression of synapsins
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Abstract
The synapsin family consists of three neuronal-specific phosphoproteins associated
with dynamic reorganization of the neuronal cytoskeleton. Synapsin I and II are implicated
in axonal and synaptic differentiation, formation and maintenance, whereas the function
of synapsin III is not as well defined. We report a significant transcriptional upregulation
of all three synapsins (synapsin I, 2.1-fold; synapsin II, 2.6-fold; and synapsin
III, 5.5-fold) by retinoic acid-induced differentiation of NTera-2cl.D1 cells, a human
paradigm for neuronal differentiation. The observed stronger regulation of synapsin
III might be due to still active neurite elongation and a rather early state of presynaptic
maturation at the time-point investigated, as synapsin III was previously found to
be highly enriched in growth cones and during early synaptic development.