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      Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B.

      Annals of Neurology
      Adult, Amyloid beta-Peptides, analysis, Aniline Compounds, diagnostic use, Brain, metabolism, physiopathology, radionuclide imaging, Brain Mapping, methods, Cerebral Amyloid Angiopathy, Cerebral Arteries, pathology, Humans, Male, Occipital Lobe, Plaque, Amyloid, Positron-Emission Tomography, Predictive Value of Tests, Thiazoles

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          Abstract

          Imaging of cerebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar beta-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.

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