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      Effects of Substance P on Anterior Pituitary Secretion in the Female Rhesus Monkey

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          Abstract

          The effects of substance P on anterior pituitary secretion were studied in 3 female rhesus monkeys. In nine experiments, 100 μg substance P was injected intraventricularly, and the results were compared to those obtained following intraventricular injection of the control vehicle. In 7 out of 9 experiments, substance P induced a significant increase in prolactin secretion within 5 min. Peak levels at 10 min were approximately 15-20 times those of the baseline control. Substance P also induced a slight but significant decrease in GH secretion 20 min following injection, but at other times GH levels were not significantly changed. LH and FSH as well as cortisol concentrations remained unaltered. In 2 monkeys a decrease in systolic pressure of 40–70 mm Hg within 10-60 sec and lasting 180-300 sec was observed following the administration of substance P but not the control vehicle. The results indicate that substance P, which in the monkey has been shown to be associated with hypothalamic regions implicated in the control of anterior pituitary secretion, can alter prolactin and GH release.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1980
          1980
          26 March 2008
          : 31
          : 5
          : 338-342
          Affiliations
          Institute for the Study of Reproductive Sciences, Columbia University College of Physicians and Surgeons, New York City, N.Y.
          Article
          123098 Neuroendocrinology 1980;31:338–342
          10.1159/000123098
          6160422
          © 1980 S. Karger AG, Basel

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          Pages: 5
          Categories
          Original Paper

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