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      Mechanism of Action of Indirectly Acting Sympathomimetic Amines

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          Abstract

          The mode of action of indirectly acting sympathomimetic amines was analysed in the rat vas deferens (preloaded with <sup>3</sup>H-(–)-noradrenaline). When monoamine oxidase (MAO), catechol-O-methyltransferase and vesicular uptake were inhibited (i.e., when the concentration of <sup>3</sup>H-noradrenaline in the axoplasm was high), all substrates of neuronal uptake induced a carrier-mediated outward transport of ¾noradrenaline, in strict dependence on the K<sub>m</sub> for neuronal uptake of the substrate. However, when MAO and vesicular uptake were not inhibited, some of the substrates of neuronal uptake were better releasers of <sup>3</sup>H-noradrenaline than others; obviously, when the axoplasmic <sup>3</sup>H-noradrenaline concentration is very low (intact vesicular uptake, intact MAO), a ‘mobilization’ of vesicular <sup>3</sup>H-noradrenaline is a prerequisite for substantial release.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          978-3-8055-4659-1
          978-3-318-01830-1
          1018-1172
          1423-0135
          1987
          1987
          23 September 2008
          : 24
          : 5
          : 261-270
          Affiliations
          Department of Pharmacology and Toxicology, University of Würzburg, FRG
          Article
          158702 Blood Vessels 1987;24:261–270
          10.1159/000158702
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Proceeding

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