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      A spatially extended model for macroscopic spike-wave discharges.

      Journal of Computational Neuroscience

      physiology, Nerve Net, Models, Neurological, Interneurons, Humans, physiopathology, Epilepsy, Cortical Synchronization, Cerebral Cortex, Biological Clocks, Action Potentials

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          Abstract

          Spike-wave discharges are a distinctive feature of epileptic seizures. So far, they have not been reported in spatially extended neural field models. We study a space-independent version of the Amari neural field model with two competing inhibitory populations. We show that this competition leads to robust spike-wave dynamics if the inhibitory populations operate on different time-scales. The spike-wave oscillations present a fold/homoclinic type bursting. From this result we predict parameters of the extended Amari system where spike-wave oscillations produce a spatially homogeneous pattern. We propose this mechanism as a prototype of macroscopic epileptic spike-wave discharges. To our knowledge this is the first example of robust spike-wave patterns in a spatially extended neural field model.

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          Journal
          10.1007/s10827-011-0332-1
          21556886

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