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      Parenteral Tiapamil Treatment of Arrhythmias in Cardiac Patients

      a , b

      Cardiology

      S. Karger AG

      Tiapamil, Calcium antagonist, Antiarrhythmic drug

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          Abstract

          27 cardiac patients with different types of arrhythmias were treated in the coronary care unit with tiapamil administered by intravenous infusion. Special attention was given to determining the antiarrhythmic effects in patients with acute coronary insufficiency. In the group of 15 patients with ventricular extrasystoles (VEs; Lown classification III-V), 9 patients had acute myocardial infarction and 1 patient had coronary artery disease. In the group with supraventricular extrasystoles (6 cases), 1 patient had experienced anterior infarction. The third group comprised 6 patients with combined ventricular (Lown V) and supraventricular extrasystoles. In 1 case, the arrhythmia was due to acute anterior infarction, 2 patients had experienced reinfarction and one patient had crescendo angina pectoris. ECG and hemodynamics were monitored continuously before, during and for 20 h following therapy. In patients with VEs alone, the median frequency fell from 612 to 459/h at the third hour of infusion. The median VE/sinus beat quotient decreased from 0.125 to 0.0108 (p < 0.01) in the third hour of treatment, and increased to 0.1029 after the completion of therapy. VE suppression was particularly marked in the 10 patients with coronary artery disease, 7 of these demonstrating a reduction by over 90%. Similar results were obtained in patients with supraventricular arrhythmias and mixed forms.The preliminary results show that tiapamil may be an effective antiarrhythmic agent in supraventricular and particularly in ventricular extrasystoles, and that its spectrum of antiarrhythmic action merits detailed investigation in larger numbers of patients.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-3588-5
          978-3-318-01756-4
          0008-6312
          1421-9751
          1982
          1982
          07 November 2008
          : 69
          : Suppl 1
          : 192-198
          Affiliations
          aDepartment of Cardiology, Albertinen Hospital, Hamburg; bDepartment of Clinical Investigation and Development, Hoffmann-La Roche AG, Grenzach-Wyhlen, FRG
          Article
          173555 Cardiology 1982;69:192–198
          10.1159/000173555
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Clinical Effect

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