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Abstract
Herpes gestationis (HG) is a rare, recurrent, pruritic, vesicobullous dermatosis occurring
predominantly in pregnancy and seldom in early puerperium. Reports of the association
of HG with choriocarcinoma are extremely rare and this case highlights such a possible
link.
This case focuses on the late postpartal manifestation of HG being associated with
metastatic high-risk choriocarcinoma. Direct immunofluorescence was used to verify
the diagnosis of HG. Symptomatic therapy with corticosteroids and antihistamines alleviated
the pruritic symptoms associated with HG, but only the recurrent course of chemotherapy
for the choriocarcinoma resulted in complete disappearance of all signs and symptoms
of the HG.
The time course of this case highlights once again the possible association of HG
as a paraneoplastic syndrome of choriocarcinoma.