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      Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population.

      1 , , ,

      Journal of the neurological sciences

      Elsevier BV

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          Abstract

          Migraine, a very common headache disorder, is regarded as a polygenic disease and serotonergic pathways appear to play a major role in its pathogenesis. The present study was designed to explore the associations of polymorphisms of 5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) and 5-hydroxytryptamine receptor 1B (5-HT1B) genes in Turkish migraine patients. 5-HT1A C-1019G (rs6295) promoter and 5-HT1B G861C (rs6296) exon polymorphisms in 203 migraine patients and 202 healthy subjects were analyzed by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Allele and genotype frequencies were not significantly different between migraine patients and healthy subjects for both the 5-HT1A C-1019G promoter and 5-HT1B G861C exon polymorphisms. Our data do not support the hypothesis that 5-HT1A C-1019G and 5-HT1B G861C polymorphisms have effects on migraine.

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          Author and article information

          Journal
          J. Neurol. Sci.
          Journal of the neurological sciences
          Elsevier BV
          1878-5883
          0022-510X
          Mar 15 2013
          : 326
          : 1-2
          Affiliations
          [1 ] Gaziosmanpasa University, Medical Faculty, Department of Medical Biology, 60100, Tokat, Turkey.
          S0022-510X(13)00015-4
          10.1016/j.jns.2013.01.013
          23375453

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