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      Impact of beta 2-microglobulin on tapasin expression and covalent association.

      1 , ,

      Cellular immunology

      Elsevier BV

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          Abstract

          Cellular immunity is dependent on major histocompatibility complex (MHC) class I molecules enabling cytotoxic T cell recognition of malignant and infected cells. Loading of antigenic peptides onto MHC class I is assisted by a peptide-loading protein complex including tapasin. We found that tapasin expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms. In addition, using conditions which preserve the tapasin-ERp57 disulfide-bonded conjugate, we demonstrated that beta 2-microglobulin increases tapasin-containing protein complexes, and reduces the level of MHC class I/ERp57 complexes lacking tapasin. Overall, our results provide a new perspective on the regulation of tapasin expression and association.

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          Author and article information

          Journal
          Cell. Immunol.
          Cellular immunology
          Elsevier BV
          1090-2163
          0008-8749
          Sep 2012
          : 279
          : 1
          Affiliations
          [1 ] Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
          Article
          S0008-8749(12)00174-8 NIHMS416475
          10.1016/j.cellimm.2012.09.010
          3518554
          23089196

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