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Acute and chronic complications of type 2 diabetes mellitus in children and adolescents.

Lancet

Prevalence, epidemiology, complications, Hypercholesterolemia, Humans, Dyslipidemias, mortality, Diabetic Ketoacidosis, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Chronic Disease, Child, Adolescent, Acute Disease

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      Abstract

      With the increase in prevalence of type 2 diabetes mellitus in adolescents, a rise in incidence of secondary comorbidities--including hypertension, hyperlipidaemia, nephropathy, and retinopathy--is anticipated. Furthermore, findings of studies in young adults have suggested that the development and progression of clinical complications might be especially rapid when the onset of type 2 diabetes is early, raising the possibility of a serious public-health challenge in the next few decades. To date, reports of the epidemiology and natural history of secondary complications specifically in adolescents with type 2 diabetes have been scarce. Yet, we must begin to understand the extent of the coming challenge. To this end, we have reviewed reports on acute and long-term comorbidities associated with type 2 diabetes in young people and have looked at mounting evidence that this group could be at increased risk for development of early complications.

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      Journal
      10.1016/S0140-6736(07)60821-6
      17531891

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