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      Vitamin E Inhibits Retinal Pigment Epithelium Cell Proliferation in vitro

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          Retinal pigment epithelium (RPE) cells migrating through the damaged retina play an important role in the pathogenesis of proliferative vitreoretinopathy (PVR). We found that α-tocopherol (vitamin E) inhibits proliferation of human RPE in culture without exerting cytotoxic effects. Maximal inhibition was achieved with 100 μ M α-tocopherol. Our result could explain the observation that vitamin E supplements have an adverse effect on light-damaged retina and on the course of retinitis pigmentosa. Since it has been shown that supplemental oral administrations of vitamin E can raise the RPE concentration of α-tocopherol well above 100 μ M and supplementation is not associated with any clinical relevant adverse effect, we believe that vitamin E could be beneficial in the treatment of PVR.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 26
          : 5
          : 304-309
          aUniversitäts-Augenklinik, Inselspital Bern, and bInstitut für Biochemie und Molekularbiologie, Universität Bern, Switzerland
          267493 Ophthalmic Res 1994;26:304–309
          © 1994 S. Karger AG, Basel

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