M. Zeller a , Y. Cottin a , Y. Laurent b , N. Danchin c , I. L’Huillier a , B. Collin a , J. Desgrés h , J. Ravisy d , L. Janin-Manificat e , H. Makki f , M. Jolak g , J.C. Beer a , G. Dentan e , P. Gambert h , J.E. Wolf a
28 April 2004
Methods and Results: 101 patients hospitalized for acute non-ST-elevation myocardial infarction (NSTEMI) were included in the study. Median N-terminal fragment of the brain natriuretic peptide (BNP) prohormone (Nt-proBNP) plasma level was 136 (40–335) pmol/l. Patients with increasing levels of troponin I [from low (0.1–10 ng/ml), intermediate (10–40 ng/ml) to high (≧40 ng/ml) levels] had significantly increased levels of Nt-proBNP (p < 0.05). High-risk patients classified by a high PURSUIT score (i.e. supramedian) had significantly increased Nt-proBNP levels compared to patients with low scores (p < 0.001). Moreover, patients with inhospital events (death, recurrent MI or clinical heart failure: 27%) had significantly increased median levels of Nt-proBNP compared to event-free patients (184 vs. 105 pmol/l, p = 0.02). Conclusion: Our data in an unselected population of NSTEMI patients indicate that high levels of circulating Nt-proBNP levels are associated with an increased risk of early cardiovascular events.