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      Identification of a Genotype VIId Newcastle Disease Virus Isolated from Sansui Sheldrake Ducks in Guizhou Province, China

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          Abstract

          In this study, we report the complete genome sequence of a novel Newcastle disease virus (NDV) strain, Sheldrake duck/China/Guizhou/SS1/2014, isolated from Sansui Sheldrake duck flocks in Guizhou Province, southwestern China. The genome of this isolate is 15,192 nucleotides in length, which belongs to NDV genotype VIId in class II. This discovery will help us further study the epidemiology characteristics and molecular pathogenesis of genotype VIId NDV in Sansui Sheldrake ducks.

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          A summary of taxonomic changes recently approved by ICTV.

          M. Mayo (2002)
          Article 0 comments Cited 165 times – based on 0 reviews     Review now
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            Newcastle disease virus: Current status and our understanding

            Ketan Ganar, Moushumee Das, Sugandha Sinha … (2014)
            Highlights • Historical perspective and global scenario about Newcastle disease. • Characteristics about Newcastle disease virus genome. • Replication and pathogenicity of Newcastle disease virus. • Use of Newcastle disease virus as a vaccine vector. • Newcastle disease virus as an oncolytic agent.
            Article 0 comments Cited 128 times – based on 0 reviews     Review now
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              Role of fusion protein cleavage site in the virulence of Newcastle disease virus

              Aruna Panda, Zhuhui Huang, Subbiah Elankumaran … (2003)
              Newcastle disease virus (NDV) causes a highly contagious and economically important disease in poultry. Viral determinants of NDV virulence are not completely understood. The amino acid sequence at the protease cleavage site of the fusion (F) protein has been postulated as a major determinant of NDV virulence. In this study, we have examined the role of F protein cleavage site sequence in NDV virulence using reverse genetics technology. The sequence G-R-Q-G-R present at the cleavage site of the F protein of avirulent strain LaSota was mutated to R-R-Q-K-R, which is present in the F cleavage site of neurovirulent strain Beaudette C (BC). The resultant mutated LaSota V.F. virus did not require exogenous protease for infectivity in cell culture, indicating that the F protein was cleaved by intracellular proteases. The virulence of the mutant and parental viruses was evaluated in vivo by intracerebral pathogenicity index (ICPI) and intravenous pathogenicity index (IVPI) tests in chickens. Our results showed that the modification of the F protein cleavage site resulted in a dramatic increase in virulence from an ICPI value of 0.00 for LaSota to a value of 1.12 for LaSota V.F. However, the ICPI value of LaSota V.F. was lower than that of BC, which had a value of 1.58. Interestingly, the IVPI tests showed values of 0.00 for both LaSota and LaSota V.F. viruses, compared to the IVPI value of 1.45 of BC. In vitro characteristics of the viruses were also studied. Our results demonstrate that the efficiency of cleavage of the F protein plays an important role if the NDV is delivered directly into the brains of chicks, but there could be other viral factors that probably affect peripheral replication, viremia, or entry into the central nervous system.
              Article 0 comments Cited 90 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Genome Announc
                Journal ID (iso-abbrev): Genome Announc
                Journal ID (hwp): ga
                Journal ID (pmc): ga
                Journal ID (publisher-id): GA
                Title: Genome Announcements
                Publisher: American Society for Microbiology (1752 N St., N.W., Washington, DC )
                ISSN (Electronic): 2169-8287
                Publication date (Electronic): 9 April 2015
                Publication date Collection: Mar-Apr 2015
                Volume: 3
                Issue: 2
                Electronic Location Identifier: e00161-15
                Affiliations
                [a ]Key Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, China
                [b ]College of Animal Science, Guizhou University, Guiyang, China
                Author notes
                Address correspondence to Zhiqiang Duan, as.duanzq@ 123456gzu.edu.cn .
                Article
                Publisher ID: genomeA00161-15
                DOI: 10.1128/genomeA.00161-15
                PMC ID: 4392140
                SO-VID: 27f1a628-49c8-4f6c-8f1e-e89a22ca1fe9
                Copyright © Copyright © 2015 Duan et al.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.

                History
                Date received : 5 February 2015
                Date accepted : 26 February 2015
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 15, Pages: 2, Words: 1338
                Categories
                Subject: Viruses
                Custom metadata
                cover-date March/April 2015
                access-type free

                ScienceOpen disciplines: Genetics
                Data availability:
                ScienceOpen disciplines: Genetics

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