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      About Blood Purification: 3.0 Impact Factor I 5.6 CiteScore I 0.83 Scimago Journal & Country Rank (SJR)

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      Effects of Arterial Port Design on Blood Flow Distribution in Hemodialyzers

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          Abstract

          Background/Aims: Blood flow profiles in fiber bundles depend on the design of the arterial port and affects the biocompatibility of the hemodialyzer. We analyzed the effects of arterial port design on blood flow distribution in fiber bundles using nonintrusive imaging techniques. Methods: The velocity fields in arterial ports and the hemodynamics in fiber bundles were analyzed for hemodialyzers with different configurations using particle image velocimetry and perfusion computed tomography. Results: In a hemodialyzer with standard arterial ports, high blood flow profiles in the central and peripheral regions and low blood profiles in the middle region were developed due to jet flow and vortices around the jet. In a hemodialyzer with spiral arterial ports, higher flow profiles were developed due to the central vortices that decrease perfusion into the fiber bundles. Conclusion: The arterial port design of hemodialyzers should be optimized such that jet flow and vortices do not impair dialysis efficiency and biocompatibility.

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          Most cited references13

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          Fundamentals of digital particle image velocimetry

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            Distortion compensation for generalized stereoscopic particle image velocimetry

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              Cerebral perfusion CT: technique and clinical applications.

              Perfusion computed tomography (CT) is a relatively new technique that allows rapid qualitative and quantitative evaluation of cerebral perfusion by generating maps of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). The technique is based on the central volume principle (CBF = CBV/MTT) and requires the use of commercially available software employing complex deconvolution algorithms to produce the perfusion maps. Some controversies exist regarding this technique, including which artery to use as input vessel, the accuracy of quantitative results, and the reproducibility of results. Despite these controversies, perfusion CT has been found to be useful for noninvasive diagnosis of cerebral ischemia and infarction and for evaluation of vasospasm after subarachnoid hemorrhage. Perfusion CT has also been used for assessment of cerebrovascular reserve by using acetazolamide challenge in patients with intracranial vascular stenoses who are potential candidates for bypass surgery or neuroendovascular treatment, for the evaluation of patients undergoing temporary balloon occlusion to assess collateral flow and cerebrovascular reserve, and for the assessment of microvascular permeability in patients with intracranial neoplasms. This article is a review of the technique, clinical applications, and controversies surrounding perfusion CT. Copyright RSNA, 2004
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                Author and article information

                Journal
                BPU
                Blood Purif
                10.1159/issn.0253-5068
                Blood Purification
                S. Karger AG
                0253-5068
                1421-9735
                2009
                October 2009
                14 August 2009
                : 28
                : 3
                : 260-267
                Affiliations
                aInstitute of Medical and Biological Engineering, Medical Research Center, College of Medicine, bInterdisciplinary Program in Bioengineering Major, Seoul National University, cDepartment of Mechanical Engineering, Seoul National University of Technology, dDepartment of Radiology, Seoul National University Hospital, eDepartment of Internal Medicine, Chung-Ang University Hospital, fGraduate School of Nano Information Design Fusion Technology, Seoul National University of Technology, gSchool of Mechanical and Automotive Engineering, Kookmin University, and hDepartment of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, and iDepartment of Veterinary Medicine, Jeju National University, Jeju, Republic of Korea; jDepartment of Nephrology, Dialysis and Transplantation, St. Bortolo Hospital, International Renal Research Institute Vicenza (IRRIV), Vincenza, Italy
                Article
                232934 Blood Purif 2009;28:260–267
                10.1159/000232934
                19684393
                280fdc9b-02c6-49ec-b227-3e876db29708
                © 2009 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                : 11 March 2009
                : 15 May 2009
                Page count
                Figures: 7, References: 19, Pages: 8
                Categories
                Original Paper

                Cardiovascular Medicine,Nephrology
                Dialysis efficiency,Biocompatibility,Hemodialysis,Hemodialyzer,Particle image velocimetry,Perfusion computed tomography,Blood flow distribution,Arterial port

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