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      Effect of Combined Endurance Training and MitoQ on Cardiac Function and Serum Level of Antioxidants, NO, miR-126, and miR-27a in Hypertensive Individuals

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          Abstract

          Objectives

          Hypertension (HTN) is one of the most important risk factors for cardiovascular diseases. Despite advances in treatment and control of HTN, the prevalence of HTN is still increasing. MitoQ is a supplement that acts on mitochondria and attenuates reactive oxygen species (ROS), which plays an important role in cardiovascular health. miRNAs play an important role in the pathophysiology of HTN. We evaluated the effects of MitoQ supplementation and endurance training (ET), alone and in combination, on functional indices of the heart and serum levels of miR-126, miR-27a, antioxidants, and NO, in patients with HTN.

          Methods

          In a double-blind randomized clinical trial, 52 male participants (age 40-55 years) were randomly divided into four groups ( n = 13) of placebo, MitoQ (20 mg/day, oral), ET (cycle ergometer, moderate intensity, 40-60% VO 2 peak, heart rate 120-140 b/min, 45 min a day, three days/week for six weeks), and MitoQ+ET. Cardiac function indices were assessed by echocardiography before and after interventions.

          Results

          Systolic blood pressure (SBP) significantly decreased in all intervention groups ( P < 0.001) while DBP ( P < 0.01) and LV hypertrophy ( P < 0.05) were significantly decreased only in the MitoQ+ET group. Serum levels of SOD, GPx, and NO and the level of miR-126 significantly increased in all treatment groups, while miR-27a reduced in the ET ( P < 0.05) and MitoQ+ET ( P < 0.01) groups.

          Conclusions

          Compared to MitoQ and ET alone, their combination has more prominent improving effects on cardiac health and amelioration of BP in the patients with HTN. These effects are through miR-126 and miR-27a modulation and ameliorating mitochondrial ROS production.

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          Most cited references49

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          Psychophysical bases of perceived exertion

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            Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology.

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              Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.

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                Author and article information

                Contributors
                Journal
                Biomed Res Int
                Biomed Res Int
                BMRI
                BioMed Research International
                Hindawi
                2314-6133
                2314-6141
                2022
                13 January 2022
                : 2022
                : 8720661
                Affiliations
                1Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
                2Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
                3Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, and Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
                4Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
                Author notes

                Academic Editor: Vickram Ramkumar

                Author information
                https://orcid.org/0000-0002-6488-4103
                https://orcid.org/0000-0002-8030-8704
                https://orcid.org/0000-0001-5942-2003
                https://orcid.org/0000-0003-3651-3505
                https://orcid.org/0000-0003-1861-5161
                Article
                10.1155/2022/8720661
                8776465
                35071600
                28336521-51d6-4019-92b1-41f71f73fbb5
                Copyright © 2022 Yaser Masoumi-Ardakani et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 24 April 2021
                : 17 December 2021
                Funding
                Funded by: Research and Technology of Kerman University of Medical Sciences, Kerman, Iran
                Award ID: 97000973
                Categories
                Research Article

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