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      Cardiac Function and Oxygen Balance in Septic Patients during Continuous Hemofiltration

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          The aim of this work was to study hemodynamic, oximetric and metabolic parameters in septic patients during continuous hemofiltration, in order to determine whether the changes in hemodynamic parameters can influence the oxygen utilization in peripheral tissues. 29 multiple organ failure patients with septic shock were studied during the first 48 h of continuous hemofiltration: 18 were submitted to CAVH and 11 patients were treated with CAVHD to correct ARF and fluid overload. Our data show that RVEF improves and REDVI reduces progressively during treatment, together with a significant reduction of the cardiac index after 48 h of CAVH(D). There were no significant variations in oxygen tissue parameters, while plasma lactate was reduced significantly. In conclusion, our data confirm that continuous hemofiltration may be useful in septic patients to correct fluid overload and ARF, without affecting hemodynamic stability and oxygen balance. Moreover, in septic patients, this technique improves hemodynamics, reduces the filling pressure in the right heart and reduces hyperdynamic response as CI and SVRI, without any negative effects on O<sub>2</sub> balance.

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          Removal of platelet-activating factor in experimental continuous arteriovenous hemofiltration


            Author and article information

            Blood Purif
            Blood Purification
            S. Karger AG
            June 1998
            08 July 1998
            : 16
            : 3
            : 140-146
            a Institute of Tissue Typing, NCR, L’Aquila, b Surgical Clinic, Tor Vergata University, Rome, c Anesthesiology Clinic, Tor Vergata University, Rome, d Nephrology Division, GB Grassi Hospital, USL RMD, Rome, Italy
            14327 Blood Purif 1998;16:140–146
            © 1998 S. Karger AG, Basel

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            Page count
            Pages: 7
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/14327
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