Cardiac Function and Oxygen Balance in Septic Patients during Continuous Hemofiltration

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Abstract

The aim of this work was to study hemodynamic, oximetric and metabolic parameters in septic patients during continuous hemofiltration, in order to determine whether the changes in hemodynamic parameters can influence the oxygen utilization in peripheral tissues. 29 multiple organ failure patients with septic shock were studied during the first 48 h of continuous hemofiltration: 18 were submitted to CAVH and 11 patients were treated with CAVHD to correct ARF and fluid overload. Our data show that RVEF improves and REDVI reduces progressively during treatment, together with a significant reduction of the cardiac index after 48 h of CAVH(D). There were no significant variations in oxygen tissue parameters, while plasma lactate was reduced significantly. In conclusion, our data confirm that continuous hemofiltration may be useful in septic patients to correct fluid overload and ARF, without affecting hemodynamic stability and oxygen balance. Moreover, in septic patients, this technique improves hemodynamics, reduces the filling pressure in the right heart and reduces hyperdynamic response as CI and SVRI, without any negative effects on O<sub>2</sub> balance.

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Removal of platelet-activating factor in experimental continuous arteriovenous hemofiltration

Claudio Ronco, Ciro Tetta, Alessandro Lupi … (1995)

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Author and article information

Journal

Journal ID (publisher-id): BPU

Journal ID (nlm-ta): Blood Purif

Journal ID (doi): 10.1159/issn.0253-5068

Title: Blood Purification

Publisher: S. Karger AG

ISSN (Print): 0253-5068

ISSN (Electronic): 1421-9735

Publication date Subscription-year: 1998

Publication date (Print): June 1998

Publication date (Electronic): 08 July 1998

Volume: 16

Issue: 3

Pages: 140-146

Affiliations

^a Institute of Tissue Typing, NCR, L’Aquila, ^b Surgical Clinic, Tor Vergata University, Rome, ^c Anesthesiology Clinic, Tor Vergata University, Rome, ^d Nephrology Division, GB Grassi Hospital, USL RMD, Rome, Italy

Article

Publisher ID: 14327 Other ID: Blood Purif 1998;16:140–146

DOI: 10.1159/000014327

PubMed ID: 9681156

SO-VID: 28388325-4bc0-422d-8fc4-ccd4a25073a3

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