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      Effect of Exercise and Isoprenaline on Left Ventricular Ejection Fraction in Patients with Angina pectoris as Assessed by Radionuclide Angiography

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          Abstract

          The effect of supine leg exercise and an infusion of isoprenaline (2 µg/min) have been compared in 9 patients with angina pectoris and 8 normal control subjects. Left ventricular ejection fraction was measured by radionuclide angiography using the gated blood pool technique. The normal subjects increased their ejection fraction from 0.57 ± 0.02 at rest to 0.71 ± 0.02 during exercise, and 0.76 ± 0.03 during isoprenaline infusion. In patients with angina pectoris, the resting ejection fraction of 0.47 ± 0.04 decreased to 0.35 ± 0.04 during exercise but increased to 0.63 ± 0.06 during isoprenaline infusion. Our results suggest that the changes in ejection fraction probably depend on the changes in left ventricular segmental wall motion. When dyskinesia is increased, as with exercise, the ejection fraction declines, but when dyskinesia is unaffected or improved, as with isoprenaline, the ejection fraction increases.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1982
          1982
          07 November 2008
          : 69
          : 2
          : 91-97
          Affiliations
          Department of Medicine, and the Department of Medical Physics and Engineering, Royal Infirmary, Edinburgh, Scotland
          Article
          173489 Cardiology 1982;69:91–97
          10.1159/000173489
          7105072
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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