18
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Interleukin-1 Stimulates Hypothalamic Inhibitory Amino Acid Neurotransmitter Release

      review-article
      , , ,
      Neuroimmunomodulation
      S. Karger AG
      IL-1, GABA, Taurine, Glycine, Hypothalamus

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Interleukin-1 (IL-1), a polypeptide cytokine, has been postulated as a chemical messenger between the immune and the neuroendocrine system. IL-1 receptors and immunopositive neurons have been visualized in the human and rat hypothalamus, suggesting that IL-1 can act as a neurotransmitter within the brain. In the hypothalamus IL-1 and the amino acid neurotransmitters are known to modulate several functions, such as fever, anorexia and the gonadal and adrenal axis. Since the hypothalamic actions of IL-1 on the amino acid neurotransmitter output are unknown, the aim of the present paper was to evaluate the effects of IL-1 on the hypothalamic release of both, the inhibitory taurine, glycine and GABA and the excitatory glutamate, amino acid neurotransmitters. Intact adult male rats were employed. The preoptic/mediobasal hypothalamic area was dissected and superfused with Earle’s balanced salt solution. Superfusate fractions were collected after a 60-min stabilization period. Following 60 min of basal release, IL-1 was added to the superfusion medium over 30 min. GABA, taurine and glycine release were significantly (p < 0.05) increased in the superfusion medium, while glutamate was not modified compared with the control group. These observations show that IL-1 increased GABA, taurine and glycine release. These effects indicate that this cytokine can affect the hypothalamic inhibitory amino acid output, which may help us to understand the mechanism by which IL-1 exerts its effects.

          Related collections

          Most cited references3

          • Record: found
          • Abstract: not found
          • Article: not found

          Taurine in the central nervous system and the mammalian actions of taurine

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Amino acid neurotransmitters and their pathways in the mammalian central nervous system.

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Immunoreactive interleukin-1β localization in the rat forebrain

                Bookmark

                Author and article information

                Journal
                NIM
                Neuroimmunomodulation
                10.1159/issn.1021-7401
                Neuroimmunomodulation
                S. Karger AG
                1021-7401
                1423-0216
                1998
                April 1998
                10 July 1998
                : 5
                : 1-2
                : 1-4
                Affiliations
                Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
                Article
                26319 Neuroimmunomodulation 1998;5:1–4
                10.1159/000026319
                9698251
                28403a55-064c-4fe3-8d2f-c5183d67e30f
                © 1998 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Page count
                Pages: 4
                Categories
                Rapid Communication

                Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
                IL-1,Taurine,GABA,Glycine,Hypothalamus

                Comments

                Comment on this article