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      Serum Glycated Albumin and Fructosamine in Renal Dialysis Patients

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          Abstract

          The effect of uraemia on protein glycation was studied by measuring glycated albumin and fructosamine in 50 non-diabetic dialysis patients (31 continuous ambulatory peritoneal dialysis, CAPD, 19 haemodialysis). After correction for serum albumin concentration, glycated albumin (g/l00 g) was increased in the haemodialysis group (1.94 ± 0.40) compared with both CAPD patients (1.46 ± 0.37; p < 0.001) and controls (1.52 ± 0.29; p < 0.001), but did not differ between CAPD patients and controls (p > 0.05). Serum fructosamine, corrected for either serum albumin or total protein concentration (μmol/100 g), was raised in CAPD (828 ± 90, 386 ± 41, respectively) and haemodialysis patients (802 ± 123, 391 ± 42, respectively) compared with controls (609 ± 69, 332 ± 27, respectively; p < 0.0001 in all cases), but did not differ between the two dialysis groups (p > 0.05). A single haemodialysis cycle had no effect on the measurement of glycated albumin or fructosamine (p > 0.05). The results confirm that glycated protein levels are generally raised in dialysis patients. In CAPD patients, altered albumin metabolism resulting from large peritoneal losses is likely to have caused a decrease in the amount of albumin glycated, an effect less apparent on the concentration of fructosamine because of the additional contribution of glycated globulins.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1993
          1993
          12 December 2008
          : 64
          : 1
          : 82-88
          Affiliations
          Departments of aChemical Pathology and bNephrology, Renal Research Laboratory, St. Bartholomew’s Centre for Clinical Research, St. Bartholomew’s Hospital, and cDepartment of Chemical Pathology, Homerton Hospital, London, UK
          Article
          187283 Nephron 1993;64:82–88
          10.1159/000187283
          8502341
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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