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      Grading of peripheral cytopenias caused by nonalcoholic cirrhotic portal hypertension and its clinical significance.

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          Abstract

          This study investigates peripheral cytopenias in patients with splenomegaly caused by nonalcoholic cirrhotic portal hypertension. Data from 330 splenomegaly cases caused by nonalcoholic cirrhotic portal hypertension were collected and analyzed using univariate and multivariate analysis. The cytopenias were scored and graded according to the F value of the multiple linear regression equation. Based on the severity of thrombocytopenia, cytopenia was graded as mild, moderate, or severe, and determined by a score of <2 points, 2-3 points, and >3 points. 30 % of the patients had monolineage cytopenias, 35.8 % had bilineage cytopenias, and 34.2 % had trilineage cytopenias. All patients were treated surgically. In the univariate analysis, the severity of erythropenia was different in the surgical outcome when compared to the intra-group (P < 0.05). In the multivariate analysis, thrombocytopenia was different in the surgical outcomes when compared with leukopenia and erythropenia (P < 0.05). There was a significant difference in surgical outcomes between the three grades (mild, moderate, and severe) of cytopenia (P < 0.05). Peripheral cytopenias have a significant impact on the clinical outcomes. The more severe the cytopenias, the worse the surgical outcomes are. Thrombocytopenia is a major factor influencing surgical outcomes. The thrombocytopenia-based three-level grading of cytopenias provides a basis for analyzing individual cases, planning treatment, and assessing prognosis in clinical practice.

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          Author and article information

          Journal
          Cell Biochem. Biophys.
          Cell biochemistry and biophysics
          1559-0283
          1085-9195
          Mar 2015
          : 71
          : 2
          Affiliations
          [1 ] Department of General Surgery, Hainan Provincial People's Hospital, Haikou, 570311, China, yunfu_lv@126.com.
          Article
          10.1007/s12013-014-0321-x
          25377543
          287cc181-ec03-4835-9571-92956118033c
          History

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