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      The self-tuning neuron: synaptic scaling of excitatory synapses.

      1
      Cell
      Elsevier BV

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          Abstract

          Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that neurons detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites. Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          1097-4172
          0092-8674
          Oct 31 2008
          : 135
          : 3
          Affiliations
          [1 ] Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. turrigiano@brandeis.edu
          Article
          NIHMS179036 S0092-8674(08)01298-1
          10.1016/j.cell.2008.10.008
          2834419
          18984155
          287dfcba-3823-40b0-885b-7693b7fff90d
          History

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