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      Will the Third Wave of Coronavirus Disease 2019 Really Come in Korea?

      brief-report
      1 , 2 ,
      Journal of Korean Medical Science
      The Korean Academy of Medical Sciences

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          Abstract

          I personally predicted that about 10,000 people would be diagnosed with coronavirus disease 2019 (COVID-19) around March 10, based on a regression calculation that was estimated from last week's trend provided by the Korean Centers for Disease Control and Prevention.1 However, since March 5, the number of confirmed patients began to slow down slightly, and as of March 8, the inclination is clearly slowing down. If this new trend continues at this pace, I hope that the number of confirmed cases could decline by next week. However, will this plague go away as easily as we would want it to be? If the third tide comes back, all hope is gone and the vicious cycle begins again. At this point, I would like to point out what conditions must be met for the third wave to come. 1) A brand new mutant virus: No matter how much it rampages through the whole country, the disease eventually dies out because the herd immunity will be established someday. However, what if the coronavirus that comes back is not the same as the previous one and, therefore, we are not ready for the immunity against it? Nightmares begin again. It's even worse. What's really disturbing is that there is really a report about new mutations actually emerging.2 I don't know how much reliable this report is, but in any case, it is clear that mutants have appeared. 2) Another outbreak from other than religious or political rally, i.e., school or long-term care facility: As we have seen clearly in this situation, the plague explodes when two conditions are met: a close contact group in an isolated/closed space. Although the rally of religion, politics, and fellowship is now banned, the possibility of another outbreak is minimized, but there is still a trigger. I think there are two main types. One is an outbreak from a school, the other is from a nursing home or a long-term care facility (I will exclude a cruise ship because at least it can be quarantined at sea). The former will not need any further explanation and, above all, the latter is more concerned. In the former case, healthy young people are the main members, but in the latter the people have lots of handicaps such as old age and underlying chronic diseases. Rather, even now, although small and intermittent, news of a few outbreaks at a nursing home or long-term care facilities is being heard. What if this explodes on a massive scale? 3) Import from a foreign country: As mentioned earlier, mutations have been reported. Therefore, if a new outbreak due to new mutants begins, I think it is likely to be in China. There is no objection to the fact that restrictions on immigration from China are now meaningless given the current domestic situation of community infections in Korea, although, to be honest, I do not completely agree with the opinion. However, if a new wave by mutants begins in China, we will have to seriously discuss the restriction of entry from China again. As we have already been greatly affected by this plague, I think we should ban immigration from China to prevent further spread at that time. Therefore, the countermeasure is naturally conceived. Although the emergence of new mutations cannot be prevented, it is necessary to prepare for the possibility of the big outbreaks in schools and nursing homes, and to re-consider restrictions on entry from China.

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          Most cited references1

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          On the origin and continuing evolution of SARS-CoV-2

          ABSTRACT The SARS-CoV-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus (SARSr-CoV; RaTG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain (RBD) of the spike seen in SARS-CoV-2 and viruses from pangolin SARSr-CoVs are likely caused by mutations and natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses evolved into two major types (designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. Although the L type (∼70%) is more prevalent than the S type (∼30%), the S type was found to be the ancestral version. Whereas the L type was more prevalent in the early stages of the outbreak in Wuhan, the frequency of the L type decreased after early January 2020. Human intervention may have placed more severe selective pressure on the L type, which might be more aggressive and spread more quickly. On the other hand, the S type, which is evolutionarily older and less aggressive, might have increased in relative frequency due to relatively weaker selective pressure. These findings strongly support an urgent need for further immediate, comprehensive studies that combine genomic data, epidemiological data, and chart records of the clinical symptoms of patients with coronavirus disease 2019 (COVID-19).
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            Author and article information

            Journal
            J Korean Med Sci
            J. Korean Med. Sci
            JKMS
            Journal of Korean Medical Science
            The Korean Academy of Medical Sciences
            1011-8934
            1598-6357
            09 March 2020
            16 March 2020
            : 35
            : 10
            : e110
            Affiliations
            [1 ]Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
            [2 ]Division of Infectious Diseases, Department of Internal Medicine, Bucheon St. Mary's Hospital, Bucheon, Korea.
            Author notes
            Address for Correspondence: Jin-Hong Yoo, MD, PhD. Division of Infectious Diseases, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, Bucheon 14647, Republic of Korea. jhyoo@ 123456catholic.ac.kr
            Author information
            https://orcid.org/0000-0003-2611-3399
            Article
            10.3346/jkms.2020.35.e110
            7073318
            32174068
            288fdd73-7a84-403f-a19f-10b0ee562ab7
            © 2020 The Korean Academy of Medical Sciences.

            This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

            History
            : 08 March 2020
            : 08 March 2020
            Categories
            Opinion
            Infectious Diseases, Microbiology & Parasitology

            Medicine
            Medicine

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