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      Central nervous system control of food intake and body weight

      , , , ,
      Nature
      Springer Science and Business Media LLC

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          Abstract

          The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          0028-0836
          1476-4687
          September 2006
          September 2006
          : 443
          : 7109
          : 289-295
          Article
          10.1038/nature05026
          16988703
          28acbdc2-e457-4a40-b8ff-56cf1eef826e
          © 2006

          http://www.springer.com/tdm

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