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      Thyrotropin Effect on Cyclic 3’, 5’ – Nucleotide Phosphodiesterase Intracellular Distribution

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          Abstract

          Upon treatment with TSH the intracellular location of 3’, 5’-nucleotide phospho diesterase changes with time. Before hormonal treatment the histochemical reaction detects the enzyme at the periphery of the thyroidocyte. One hour after TSH administration the enzyme seems concentrated at the apical part of the cells. Two hours after hormonal treatment the stain appears scattered throughout the cytoplasm. The coincidence of enzyme location with the possible cyclic AMP sites of action is stressed.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1974
          1974
          21 November 2008
          : 5
          : 2
          : 65-75
          Affiliations
          Institute of Internal Medicine, Academic Chair for Medical Pathology (Head: Prof. G. Pende), University of Genova, Genova
          Article
          178620 Horm Res 1974;5:65–75
          10.1159/000178620
          4130025
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 11
          Categories
          Paper

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