Blog
About

  • Record: found
  • Abstract: found
  • Article: found
Is Open Access

Discerning key parameters influencing high productivity and quality through recognition of patterns in process data

1 , 1 , 2 , 2 , 2 , 3 , , 1

BMC Proceedings

BioMed Central

22nd European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies

15-18 May 2011

Read this article at

Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Related collections

      Most cited references 4

      • Record: found
      • Abstract: found
      • Article: not found

      Optimal and consistent protein glycosylation in mammalian cell culture.

      In the biopharmaceutical industry, mammalian cell culture systems, especially Chinese hamster ovary (CHO) cells, are predominantly used for the production of therapeutic glycoproteins. Glycosylation is a critical protein quality attribute that can modulate the efficacy of a commercial therapeutic glycoprotein. Obtaining a consistent glycoform profile in production is desired due to regulatory concerns because a molecule can be defined by its carbohydrate structures. An optimal profile may involve a spectrum of product glycans that confers a desired therapeutic efficacy, or a homogeneous glycoform profile that can be systemically screened for. Studies have shown some degree of protein glycosylation control in mammalian cell culture, through cellular, media, and process effects. Studies upon our own bioprocesses to produce fusion proteins and monoclonal antibodies have shown an intricate relationship between these variables and the resulting protein quality. Glycosylation optimization will improve therapeutic efficacy and is an ongoing goal for researchers in academia and industry alike. This review will focus on the advancements made in glycosylation control in a manufacturing process, as well as the next steps in understanding and controlling protein glycosylation.
        Bookmark
        • Record: found
        • Abstract: not found
        • Article: not found

        Quality by design for biopharmaceuticals.

          Bookmark
          • Record: found
          • Abstract: found
          • Article: not found

          Mining bioprocess data: opportunities and challenges.

          Modern biotechnology production plants are equipped with sophisticated control, data logging and archiving systems. These data hold a wealth of information that might shed light on the cause of process outcome fluctuations, whether the outcome of concern is productivity or product quality. These data might also provide clues on means to further improve process outcome. Data-driven knowledge discovery approaches can potentially unveil hidden information, predict process outcome, and provide insights on implementing robust processes. Here we describe the steps involved in process data mining with an emphasis on recent advances in data mining methods pertinent to the unique characteristics of biological process data.
            Bookmark

            Author and article information

            Affiliations
            [1 ]Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA
            [2 ]Roche Diagnostics GmbH, 82377 Penzberg, Germany
            [3 ]Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA
            Contributors
            Conference
            BMC Proc
            BMC Proceedings
            BioMed Central
            1753-6561
            2011
            22 November 2011
            : 5
            : Suppl 8
            : P91
            3284936
            22373092
            1753-6561-5-S8-P91
            10.1186/1753-6561-5-S8-P91
            Copyright ©2011 Le et al; licensee BioMed Central Ltd.

            This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

            22nd European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies
            Vienna, Austria
            15-18 May 2011
            Categories
            Meeting Abstract

            Medicine

            Comments

            Comment on this article