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      Effects of Complement Depletion on Experimental Allergic Uveitis


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          The immunopathologic response of guinea pigs to sensitization with retinal ‘s’ antigen has a biphasic character that is dose-dependent. At low dose levels, a non-necrotizing posterior segment inflammation is observed. At high dose levels an acute necrotizing panophthalmitis is observed. Complement depletion markedly modulates the inflammation observed following sensitization with high dose levels but appears to have no effect on the outcome of the low dose sensitization. The dose-response correlation in the inflammatory reactions induced by sensitization with retinal ‘s’ antigen may reflect the role of antibody when high doses of ‘s’ antigen are employed and the role of cell mediated immunity where low doses of antigen are employed.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 11
          : 2
          : 97-107
          Department of Ophthalmology, Georgetown University, Washington, D.C., Department of Ophthalmology, University of Louisville, Louisville, and Department of Pathology, University of Connecticut, Storrs, Conn.
          264991 Ophthalmic Res 1979;11:97–107
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 16 February 1979
          : 12 March 1979
          Page count
          Pages: 11
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Experimental allergic uveitis,Retinal ‘s’ antigen,Cell mediated immunity,Complement depletion,Immune complex disease


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